Invisible burden of COVID-19: enzyme replacement therapy disruptions

Care Burden of Home Caregivers of Patients with COVID-19

Background and purpose: Caring for patients with COVID-19 at home is mainly the responsibility of the family which leads to high burden of care. The burden of care refers to psychological pain, physical problems, financial and social pressures, disruption of family relationships, feelings of hopelessness, and other negative consequences of care tasks. The aim of this study was to determine the ...

Pancreatic Enzyme Replacement Therapy

Patients with chronic pancreatic insufficiency develop improper digestion due to the lack of digestive pancreatic enzymes. Such patients might complain of diarrhea and multi-nutrient deficiencies. Children with cystic fibrosis are at an increased risk of developing pancreatic insufficiency, while adults can develop chronic pancreatitis due to gallbladder disease or alcohol consumption. Regardle...

India's invisible malaria burden.

Significance of exosomes in COVID-19 pathogenesis and therapy

Exosomes are lipid bilayer-enclosed nano-sized vesicles, which carry various biomolecules including proteins, lipids, and microRNAs. SARS-CoV-2-loaded exosomes can be entered into the susceptible host cells, and transported viral components which are associated with viral particles intercellular transmission and spread of infection. Over-stimulation of the immune system followed by excessive pr...

Imaging of enzyme replacement therapy using PET.

Direct enzyme replacement therapy (ERT) has been introduced as a means to treat a number of rare, complex genetic conditions associated with lysosomal dysfunction. Gaucher disease was the first for which this therapy was applied and remains the prototypical example. Although ERT using recombinant lysosomal enzymes has been shown to be effective in altering the clinical course of Gaucher disease...